Cell and tissue mechanics in embryogenesis


We develop numerical tools for inferring the forces that drive morphogenesis. By combining direct and inverse analysis we simulate embryo development of epithelia and tissues. We solve these problems resorting to in-house codes that are based on either continuum and hybrid vertex/cell-centred approaches. We are currently testing regulatory process of cell contractility, cell reorganisation and cytoskeletal remodelling, and enhancing inter- and intra-cellular rheology with specific laws of active matter that mimic measured viscoelastic response. We have applied the methods to Drosophila invagination, central neural system condensation, collective cell migration and wound healing process. On a lower scale we also simulate stress relaxation and fluidisation of monolayers.


Group Leader


José Muñoz

Associate Professor
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Post Doc Researcher


Payman Mosaffa


Undergraduate Students


Daniel Alcaraz