Cell and tissue mechanics in embryogenesis

Research

We develop numerical tools for inferring the forces that drive morphogenesis. By combining direct and inverse analysis we simulate embryo development of epithelia and tissues. We solve these problems resorting to in-house codes that are based on either continuum and hybrid vertex/cell-centred approaches. We are currently testing regulatory process of cell contractility, cell reorganisation and cytoskeletal remodelling, and enhancing inter- and intra-cellular rheology with specific laws of active matter that mimic measured viscoelastic response. We have applied the methods to Drosophila invagination, central neural system condensation, collective cell migration and wound healing process. On a lower scale we also simulate stress relaxation and fluidisation of monolayers.

People

Group Leader

 

José Muñoz

Associate Professor
j.munoz@upc.edu
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Ph. D Students

 

Payman Mosaffa

payman.mosaffa@upc.edu

Undergraduate Students

 

Daniel Alcaraz