Our current efforts focus on the description of the smaller scales of biological tissues. We focus on understanding and defining the motility of single cell as well as interactions of cell aggregates by means of mathematical tools. We are particularly interested in the interaction between mechanical clues and the intra-cellular chemical balance. We are also interested in bridging the gap between the organ level, e.g. the brain, or organoids and the subcellular level, e.g. adhesion molecules and actin dynamics. Our modeling approaches cover multidisciplinary aspects of biology, mathematical models and state-of-the-art numerical methods.
A complementary energy approach accommodates scale differences in soft tissues
Saez, P.; Eppell S.J.; Ballarini R.; Rodriguez Matas J.F.
Journal of the Mechanics and Physics of Solids, Vol. 138, 2020
Computational modeling of epithelial wound healing: Short and long term chemo-mechanical mechanisms
Roldan, L.; Muñoz, J.J.; Saez, P.
Computer Methods in Applied Mechanics and Engineering, Vol. 350, pp. 28-56, 2019
On the Theories and Numerics of Continuum Models for Adaptation Processes in Biological Tissues
Archives of Computational Methods in Engineering, Vol. 23, pp. 301-322, 2015
Microstructural quantification of collagen fiber orientations and its integration in constitutive modeling of the porcine carotid artery
Saez, P.; Garcia, A.; Peña, E.; Gasser, C.; Martinez, M.A.
Acta Biomaterialia, Vol. 33, pp. 183-193, 2016