Our current efforts focus on the description of the smaller scales of biological tissues. We focus on understanding and defining the motility of single cell as well as interactions of cell aggregates by means of mathematical tools. We are particularly interested in the interaction between mechanical clues and the intra-cellular chemical balance. We are also interested in bridging the gap between the organ level, e.g. the brain, or organoids and the subcellular level, e.g. adhesion molecules and actin dynamics. Our modeling approaches cover multidisciplinary aspects of biology, mathematical models and state-of-the-art numerical methods.
On the Theories and Numerics of Continuum Models for Adaptation Processes in Biological Tissues
Archives of Computational Methods in Engineering, Vol. 23, pp. 301-322, 2015
Microstructural quantification of collagen fiber orientations and its integration in constitutive modeling of the porcine carotid artery
Saez, P.; Garcia, A.; Peña, E.; Gasser, C.; Martinez, M.A.
Acta Biomaterialia, Vol. 33, pp. 183-193, 2016
Hierarchical micro-adaptation of biological structures by mechanical stimuli
Sáez, P.; Pena, E.; Doblaré, M.; Martínez, M.A.
International Journal of Solids and Structures, Vol. 50, Issues 14-15, pp. 2353-2370, 2013