Abstract2018-05-24T12:52:58+00:00

On the Theories and Numerics of Continuum Models for Adaptation Processes in Biological Tissues

Author (s): Saez, P.
Journal: Archives of Computational Methods in Engineering

Volume: 23
Pages: 301 – 322
Date: 2015

Abstract:
Computational continuum mechanics have been used for a long time to deal with the
mechanics of materials. During the last decades researches have been using many of the theoretical
models and numerical approaches of classical materials to deal with biological tissue which, in many
senses, are a much more sophisticated material. We aim to review the last achievements of continuum
models and numerical approaches on adaptation processes in biological tissues. In this review, we are
looking, in particular, at growth in terms of changes of density and/or volume as, e.g., in collagen
remodeling, wound healing, arterial thickening, etc. Furthermore, we point out some of the most
relevant limitations of the current state-of-the-art in terms of these well established computational
continuum models. In connection with these limitations, we will nish by discussing the trend lines
of future work in the eld of modeling biological adaptation, focusing on the computational approaches
and mechanics that could overcome the current drawbacks. We would also like to attract the
attention of all those researchers in classical materials (metal, alloys, composites, etc), to point
out how similar the continuum and computational models between our elds are. We hope we can
motivate them for getting their expertize in this challenging eld of research.

  
  

Bibtex:

@Article{Saez2016,
author="Saez, P.",
title="On the Theories and Numerics of Continuum Models for Adaptation Processes in Biological Tissues",
journal="Archives of Computational Methods in Engineering",
year="2016",
volume="23",
number="2",
pages="301--322",
abstract="Computational continuum mechanics have been used for a long time to deal with the mechanics of materials. During the last decades researches have been using many of the theoretical models and numerical approaches of classical materials to deal with biological tissue which, in many senses, are a much more sophisticated material. We aim to review the last achievements of continuum models and numerical approaches on adaptation processes in biological tissues. In this review, we are looking, in particular, at growth in terms of changes of density and/or volume as, e.g., in collagen remodeling, wound healing, arterial thickening, etc. Furthermore, we point out some of the most relevant limitations of the current state-of-the-art in terms of these well established computational continuum models. In connection with these limitations, we will finish by discussing the trend lines of future work in the field of modeling biological adaptation, focusing on the computational approaches and mechanics that could overcome the current drawbacks. We would also like to attract the attention of all those researchers in classical materials (metal, alloys, composites, etc), to point out how similar the continuum and computational models between our fields are. We hope we can motivate them for getting their expertize in this challenging field of research.",
issn="1886-1784",
doi="10.1007/s11831-014-9142-8",
url="http://dx.doi.org/10.1007/s11831-014-9142-8"
}