Towards the modelling of ageing and atherosclerosis effects in ApoE-/- mice aortic tissue

Author (s): Waffenschmidt, T.; Cilla, M.; Saez, P.; Perez, M.M.; Martinez, M.A.; Menzel, A.;Peña, E.
Journal: Journal of Biomechanics

Volume: 49, Issue 12
Pages: 2390 – 2397
Date: 2016

The goal of this work consists in a quantitative analysis and constitutive modelling of ageing processes associated to plaque formation in mice arteries. Reliable information on the characteristic evolution of pressure–stretch curves due to the ageing effects is extracted from previous inflation test experiments. Furthermore, characteristic age-dependent material parameters are identified on the basis of a continuum-mechanics-based parameter optimisation technique.

The results indicate that the aorta-stiffness of the healthy control mice remains basically constant irrespective of the diet-time and age. In contrast, significant differences exist within the material response and in consequence within the material parameters between the ApoE−/− and the control mice as well as for the different locations over the aorta which is underlined by our experimental observations. With regard to the temporal evolution of the material parameters, we observe that the material parameters for the ApoE−/− mice aortas exhibit a saturation-type increase with respect to age.



title = "Towards the modelling of ageing and atherosclerosis effects in ApoE-/- mice aortic tissue ",
journal = "Journal of Biomechanics ",
volume = "49",
number = "12",
pages = "2390 - 2397",
year = "2016",
note = "Cardiovascular Biomechanics in Health and Disease ",
issn = "0021-9290",
doi = "",
url = "",
author = "Tobias Waffenschmidt and Myriam Cilla and Pablo Sáez and Marta M. Pérez and Miguel A. Martínez and Andreas Menzel and Estefanía Peña",
keywords = "Ageing",
keywords = "Anisotropic biological tissues",
keywords = "Thick-walled tube",
keywords = "Parameter identification "